Effects of endurance exercise on mitochondrial efficiency, uncoupling and lipid oxidation in human skeletal muscle
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Decreased Uncoupling Protein 2 and 3 (UCP2 and UCP3) mRNA expression by endurance exercise training with and without chronic administration of nandrolone in rat heart
Introduction: The effect of regular exercise in decreasing the incidence of heart diseases is well known. The abuse of anabolic androgenic steroids (AAS) has been associated with cardiovascular disorders. Uncoupling proteins (UCPs) transport protons across the inner mitochondrial membrane thereby proton gradient can be diminished by the action of UCPs. This process will result in the uncoupl...
متن کاملEffect of Aerobic Exercise with Blood Flow Restriction on Mitochondrial Dynamics Proteins of Human Skeletal Muscles
Background: Aerobic exercise with Blood Flow Restriction (BFR) plays an important role in skeletal muscle adaptation; however, the effects of this type of exercise on mitochondrial dynamics proteins are unclear. Objective: The purpose of this study was to investigate the effect of aerobic exercise with and without BFR on mitochondrial dynamics proteins of human skeletal muscles. Methods: Pa...
متن کاملIncreased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals.
Endurance exercise training is accompanied by physiological changes that improve muscle function and performance. Several studies have demonstrated that markers of mitochondrial capacity are elevated, however, these studies tend to be performed ex vivo under conditions that yield maximal enzyme activities or in vivo but monitoring the response to exercise. Therefore, it is unclear whether basal...
متن کاملDeterioration of physical performance and cognitive function in rats with short-term high-fat feeding.
Efficiency, defined as the amount of work produced for a given amount of oxygen consumed, is a key determinant of endurance capacity, and can be altered by metabolic substrate supply, in that fatty acid oxidation is less efficient than glucose oxidation. It is unclear, however, whether consumption of a high-fat diet would be detrimental or beneficial for endurance capacity, due to purported gly...
متن کاملThe Effects of Pyruvate Dehydrogenase Kinase 4 (PDK4) Inhibition on Metabolic Flexibility during Endurance Training in Skeletal Muscles of Streptozotocin-induced Diabetic Rats
Background:Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. Pyruvate Dehydrogenase Kinase 4 (PDK4) is one of the main enzymes that play a critical role in metabolic flexibility. In current study, we examined PDK4 inhibition along with exercise training (ET) on the gene expression of Es...
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تاریخ انتشار 2007